Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects

Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects

Acute lymphoblastic leukemia (ALL), an aggressive hematologic malignancy with high incidence and treatment resistance, demands novel therapeutic approaches. Enhanced glycolysis is a hallmark of metabolic reprogramming in ALL. Quercetin (Que) demonstrates broad antitumor effects by inhibiting glycoly...

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Bibliographic Details
Main Authors: Qiuling Ma, Wenqing Liu, Yajing Su, Jue Guo, Man Zhang, Jiayuan Guo, Mingxin Liu, Wenbo Dong, Mingwei Li, Bo Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
acute lymphoblastic leukemia
quercetin
glycolysis
CAMP/PKA/CREB
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1614973/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1614973/full

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