Split RNA switch orchestrates pre- and post-translational control to enable cell type-specific gene expression

Abstract RNA switch is a synthetic RNA-based technology that controls gene expression in response to cellular RNAs and proteins, thus enabling cell type-specific gene regulation and holding promise for gene therapy, regenerative medicine, and cell therapy. However, individual RNA switches often lack...

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Bibliographic Details
Main Authors: Itsuki Abe, Hirohisa Ohno, Megumi Mochizuki, Karin Hayashi, Hirohide Saito
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60392-2
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