A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation

A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation

Summary: Wilson disease (WD) is caused by mutations of the copper-transporting gene, ATP7B, leading to abnormal copper metabolism. A better characterization of WD is essential in understanding the effects of excess copper and how it disrupts immune regulation and hematopoietic development. Furthermo...

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Main Authors: Shuya Wang, Xianlei Sun, Qingxuan Xin, Jianxiang Shi, Jin Li, Huilin Zhang, Mengjiao Xue, Fanxiang Yin, Zan Qiu, Xiaoqian Wang, Nannan Sun, Yingmei Li, Yaoyao Chen, Liyan Fu, Chaoqi Li, Shaohua Yan, Xian Zhao, Bolin Jue, Yanxia Gao, Baohong Yue, Bo Qin, Yong Jiang, Rongqun Guo
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Biological sciences
Immunology
Immune system evolution
Immune system
Immune response
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007114
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http://www.sciencedirect.com/science/article/pii/S2589004225007114

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