Pyridine indole hybrids as novel potent CYP17A1 inhibitors

Pyridine indole hybrids as novel potent CYP17A1 inhibitors

Prostate cancer (PCa) is one of the most prevalent malignancies affecting men worldwide, and androgen deprivation therapy (ADT) is a primary treatment approach. CYP17A1 inhibitors like abiraterone target the steroidogenic pathway to reduce androgen levels, but their clinical efficacy is limited by d...

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Bibliographic Details
Main Authors: Tomasz M. Wróbel, Angelika Grudzińska, Jibira Yakubu, Therina du Toit, Katyayani Sharma, Jeremiah C. Harrington, Fredrik Björkling, Flemming Steen Jørgensen, Amit V. Pandey
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
CYP17A1
enzyme inhibition
prostate cancer
inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2463014
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2463014

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