Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway

Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway

Aims: Cyclooxygenase-2 (COX-2) is an enzyme that synthesizes prostaglandins from arachidonic acid. Previous reports have indicated that COX-2 is constitutively expressed in osteogenic cells instead of being expressed only after pathogenic induction, and that it facilitates osteoblast proliferation...

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Bibliographic Details
Main Authors: Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-05-01
Series:Bone & Joint Research
Subjects:
osteogenic differentiation
bone marrow mesenchymal stromal cells
cyclooxygenase-2
p27kip1
bone marrow
mesenchymal stem cells (mscs)
gene expression
osteogenic cells
bmscs
ossification
rnas
mrna
osteoblasts
mesenchymal stromal cells
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.145.BJR-2024-0262.R2
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.145.BJR-2024-0262.R2

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