Immune–Pathological Correlates of Disease Severity in New-World Kala-Azar: The Role of Parasite Load and Cytokine Profiles

Immune–Pathological Correlates of Disease Severity in New-World Kala-Azar: The Role of Parasite Load and Cytokine Profiles

Kala-azar is a protracted disease caused by the protozoan <i>Leishmania infantum</i> (zoonotic) or <i>L. donovani</i> (anthroponotic), transmitted by sandflies. Patients present with fever, anemia, and hepatosplenomegaly, potentially progressing to hemorrhaging, secondary inf...

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Main Authors: Ingridi de Souza Sene, Dorcas Lamounier Costa, Daniele Alves Zacarias, Jailthon Carlos dos Santos, Gabriel Reis Ferreira, Daniela Rodrigues Andrade, Jorge Clarêncio de Sousa Andrade, Carlos Henrique Nery Costa
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pathogens
Subjects:
visceral leishmaniasis
<i>Leishmania infantum</i>
hemorrhage
sepsis
HIV-coinfection
mortality
Online Access:https://www.mdpi.com/2076-0817/14/7/615
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