Upregulation of cholinergic modulators Lypd6 and Lypd6b associated with autism drives anxiety and cognitive decline

Upregulation of cholinergic modulators Lypd6 and Lypd6b associated with autism drives anxiety and cognitive decline

Abstract Intellectual disability and autistic features are associated with chromosome region 2q23.q23.2 duplication carrying LYPD6 and LYPD6B genes. Here, we analyzed LYPD6 and LYPD6B expression in patients with different neuropsychiatric disorders. Increased LYPD6 and LYPD6B expression was revealed...

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Main Authors: Aizek B. Isaev, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Alexander A. Andreev-Andrievskiy, Mikhail A. Mashkin, Mikhail A. Shulepko, Olga V. Shlepova, Eugene V. Loktyushov, Alexander V. Latanov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02211-z
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https://doi.org/10.1038/s41420-024-02211-z

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