Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer

Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer

Background: Indoleamine 2,3-dioxygenase (IDO1) activity, measured by kynurenine/tryptophan (K:T) ratio, is known for its association with distant metastasis and overall survival (OS) in patients with non-small cell lung cancer (NSCLC). Here, we aimed to examine whether IDO1 activity is correlated wi...

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Main Authors: Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Journal of the National Cancer Center
Subjects:
Indoleamine 2,3-dioxygenase
Brain metastasis
Immunosuppressive biomarker
Non-small cell lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2667005424001170
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