Latent tuberculosis coinfection in mild COVID-19 is associated with a distinct immune cell phenotype marked by enhanced cytotoxic degranulation and mitochondrial alterations

Latent tuberculosis coinfection in mild COVID-19 is associated with a distinct immune cell phenotype marked by enhanced cytotoxic degranulation and mitochondrial alterations

IntroductionThe chronic nature of latent tuberculosis infection (LTBI) allows it to coexist with diverse pathologies. However, it remains unclear whether immune alterations associated with LTBI influence COVID-19 coinfection and patient outcomes. This study aims to compare the immune phenotype of pa...

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Main Authors: Carlos Peña-Bates, Lucero A. Ramón-Luing, Julio Flores-Gonzalez, Enrique Espinosa, María F. Martinez-Moreno, Karen Medina-Quero, Marco A. Vargas-Hernandez, Norma A. Téllez-Navarrete, Fernando M. Sosa-Gomez, Eduardo Becerril-Vargas, Miguel Ángel Salazar, Leslie Chavez-Galan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
latent tuberculosis
COVID-19
coinfection
T lymphocytes
mitochondrial changes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566449/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566449/full

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