Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ‐secretase inhibitor drug responses

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ‐secretase inhibitor drug responses

Abstract Increasing evidence suggests that stem‐like cells mediate cancer therapy resistance and metastasis. Breast tumour‐initiating stem cells (T‐ISC) are known to be enriched in CD44+CD24neg/low cells. Here, we identify two T‐ISC subsets within this population in triple negative breast cancer (TN...

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Main Authors: Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews‐Elger, Xiaoqing Han, Manuel Picon‐Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El‐Ashry, Joyce M. Slingerland
Format: Article
Language:English
Published: Springer Nature 2013-08-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer stem cells
GSI
metastasis
Notch1
Sox2
Online Access:https://doi.org/10.1002/emmm.201302558
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https://doi.org/10.1002/emmm.201302558

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