PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain

PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain

Abstract Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual disability, neurodevelopmental abnormality, macrocephaly, and white matter anomaly in children. Oligodendroglial lineage cells undergo extensive proliferation and population expansion in human and rodent brain during e...

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Bibliographic Details
Main Authors: Yan Wang, Bokyung Kim, Xiangyi Shi, Huimin Chen, Joohyun Park, Meina Zhu, Evelyn M. Wong, Audrey Y. Park, Jonathan Chernoff, Fuzheng Guo
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
PAK1
p21-activated kinase 1
Oligodendrocyte
OPC proliferation
Homeostatic brain
Demyelinating brain
Online Access:https://doi.org/10.1007/s00018-025-05728-3
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https://doi.org/10.1007/s00018-025-05728-3

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