Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

BackgroundAnti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. However, challenges such as cytokine release syndrome, T cell dysfunction, and exhaustion persist. Enhancing CAR-T cell efficacy through changing CAR i...

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Bibliographic Details
Main Authors: Shufeng Xie, Jinlan Long, Ruiheng Wang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
car-t
transmembrane domain
internalization
recycling
exhaustion
cytokine release
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531344/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531344/full

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