ERK1/2 Signaling in Intrahepatic Cholangiocarcinoma: From Preclinical Advances to Therapeutic Strategies

ERK1/2 Signaling in Intrahepatic Cholangiocarcinoma: From Preclinical Advances to Therapeutic Strategies

Extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in the regulation of the key cellular processes that are essential for the proper functioning of the cell under physiological conditions. Notably, the hyperactivation of ERK1/2 is implicated in oncogenesis and metastatic dissemination ac...

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Bibliographic Details
Main Authors: Veronica Porreca, Luca Sallustio, Ludovica Giancola, Pietro Angelone, Giuseppina Mignogna, Bruno Maras, Carmine Mancone
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biology
Subjects:
ERK1/2
intrahepatic cholangiocarcinoma
target therapy
personalized medicine
tumor microenvironment
Online Access:https://www.mdpi.com/2079-7737/14/7/776
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