A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers

A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers

Abstract Background While high-grade serous ovarian cancer (HGSC) has proven largely resistant to immunotherapy, sporadic incidents of partial and complete response have been observed in clinical trials and case reports. These observations suggest that a molecular basis for effective immunity may ex...

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Bibliographic Details
Main Authors: Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
High grade serous ovarian cancer
Immunogenicity
Immune activation
Immunosuppression
Immune evasion
Mutational burden
Online Access:https://doi.org/10.1186/s12967-024-05846-9
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https://doi.org/10.1186/s12967-024-05846-9

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