Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats

Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats

<b>Background/Objectives:</b> Norepinephrine (NE) plays a crucial role in modulating cognitive processes via α2A-adrenoceptors (α2A-ARs) within the prefrontal cortex (PFC), an essential brain region responsible for higher cognitive functions. The α2A-ARs are found on both postsynaptic an...

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Bibliographic Details
Main Authors: Yaru Wei, Yuhan Jiao, Xiaoting He, Xiaodong Tao, Baoming Li, Xuehan Zhang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
NE
guanfacine
mEPSC
mIPSC
synaptic transmission
medial prefrontal cortex
Online Access:https://www.mdpi.com/2227-9059/13/6/1322
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