Association of HLA-A*02:01 type with efficacy and toxicity of immune checkpoint inhibitor therapy in melanoma patients: a retrospective cohort study

Association of HLA-A*02:01 type with efficacy and toxicity of immune checkpoint inhibitor therapy in melanoma patients: a retrospective cohort study

Abstract Background Immune checkpoint inhibitors (ICI) are highly effective but may induce severe or even fatal and unpredictable immune-related adverse events (irAEs). It is unclear whether human leukocyte antigen (HLA) genes contribute to the susceptibility of developing irAEs during ICI therapy....

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Bibliographic Details
Main Authors: Isabel Manger, Christina Schmitt, Carola Berking, Lars E. French, Julio Vera-Gonzalez, Lucie Heinzerling
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Predictive marker
IrAE
Risk factor
Immunotherapy
Genetic factors
Online Access:https://doi.org/10.1186/s12885-025-13857-y
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https://doi.org/10.1186/s12885-025-13857-y

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