Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta-42 (Aβ-42) in the brain, causing various adverse effects. Thus, therapies that reduce Aβ-42 toxicity in AD are of great interest. One promising approach is to use extracellular vesicles from human induc...

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Main Authors: Shama Rao, Leelavathi N. Madhu, Roshni Sara Babu, Goutham Shankar, Sanya Kotian, Advaidhaa Nagarajan, Raghavendra Upadhya, Esha Narvekar, James J. Cai, Ashok K. Shetty
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
Aβ-42 oligomers
Alzheimer’s disease
Apoptosis
Autophagy
Mitochondrial dysfunction
Neural stem cells
Online Access:https://doi.org/10.1186/s13287-025-04324-3
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https://doi.org/10.1186/s13287-025-04324-3

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