Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study

Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study

Abstract While chemo-immunotherapy has been established as the frontline therapeutic regimen for extensive-stage small cell lung cancer (ES-SCLC), durable responses persist predominantly in a minor population of patients. This underscores critical need to elucidate underlying local tumor microenviro...

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Main Authors: Mengqing Xie, Minwei Bao, Xiaorong Dong, Lin Wu, Li Liu, Jing Zhao, Xiangling Chu, Yan Wu, Xianxiu Ji, Yujia Fang, Xin Yu, Shiji Zhang, Qi Wang, Tao Hu, Jin Wang, Changbin Zhu, Chunxia Su
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02252-5
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https://doi.org/10.1038/s41392-025-02252-5

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