Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies
Abstract Prostate cancer (PCa) ranks among the most prevalent malignancies in men, with notable associations to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) and Lynch Syndrome, both linked to germline likely pathogenetic variant/pathogenetic variant (LPV/PV) in genes involved in DNA repair....
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2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13521-5 |
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| author | Giulia Mammone Simona Borghesi Nicolò Borsellino Anna Caliò Roberta Ceccarelli Alessia Cimadamore Giario Natale Conti Laura Cortesi Rolando Maria D’Angelillo Gaetano Facchini Lorena Incorvaia Alberto Lapini Luigi Mearini Giovanni Pappagallo Paolo Prontera Daniela Turchetti Grazia Sirgiovanni Sergio Bracarda on behalf of the Italian Society of Uro-Oncology (SIUrO) |
| author_facet | Giulia Mammone Simona Borghesi Nicolò Borsellino Anna Caliò Roberta Ceccarelli Alessia Cimadamore Giario Natale Conti Laura Cortesi Rolando Maria D’Angelillo Gaetano Facchini Lorena Incorvaia Alberto Lapini Luigi Mearini Giovanni Pappagallo Paolo Prontera Daniela Turchetti Grazia Sirgiovanni Sergio Bracarda on behalf of the Italian Society of Uro-Oncology (SIUrO) |
| author_sort | Giulia Mammone |
| collection | DOAJ |
| description | Abstract Prostate cancer (PCa) ranks among the most prevalent malignancies in men, with notable associations to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) and Lynch Syndrome, both linked to germline likely pathogenetic variant/pathogenetic variant (LPV/PV) in genes involved in DNA repair. Among these genes, BRCA2 in PCa patients is the most frequently altered. Despite progresses, challenges in BRCA carriers detection persist, with a quarter of PCa cases lacking family history. To address these challenges, a multidisciplinary expert panel from six Italian Scientific Societies, formulated a care pathway to integrate BRCA testing into routine clinical practice in different Italian geographical areas. The development process, promoted by the Italian Society of Uro-Oncology (SIUrO), involved three key stages. A preliminary meeting convened teams from different Italian regions to establish minimal requirements for a mini-counseling program (defined as a pre-test consultation carried out by clinicians responsible of patients’ management) and propose care pathway models. At the same time, a comprehensive survey was launched to highlight regional variations in BRCA testing and identify eventual obstacles to testing activities. A subsequent meeting synthesized care pathway proposals and formulated a unified framework, acknowledging regional legislative variations as enriching factors. Lastly, implementation of the unified framework was promoted by the project faculty and identified regional team leaders. Survey results revealed significant regional disparities in BRCA testing, reimbursement policies, and access to genetic counseling. The proposed mini-counseling program outlined essential steps for patient identification, information provision, and multidisciplinary review, aiming to streamline BRCA testing processes. Expert recommendations emphasized offering tumor genetic testing to metastatic PCa patients eligible for PARP-i treatment and outlined criteria for genetic counseling and germline testing. Key considerations included family history and tumor characteristics. In conclusion, the proposed care pathway represents a critical step towards integrating BRCA testing into routine PCa care, aiming to optimize patient management and familial risk assessment within the constraints of the Italian healthcare system. |
| format | Article |
| id | doaj-art-2a5c18183f04414aa181181c258f62f0 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-2a5c18183f04414aa181181c258f62f02025-01-26T12:38:09ZengBMCBMC Cancer1471-24072025-01-0125111110.1186/s12885-025-13521-5Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific SocietiesGiulia Mammone0Simona Borghesi1Nicolò Borsellino2Anna Caliò3Roberta Ceccarelli4Alessia Cimadamore5Giario Natale Conti6Laura Cortesi7Rolando Maria D’Angelillo8Gaetano Facchini9Lorena Incorvaia10Alberto Lapini11Luigi Mearini12Giovanni Pappagallo13Paolo Prontera14Daniela Turchetti15Grazia Sirgiovanni16Sergio Bracarda17on behalf of the Italian Society of Uro-Oncology (SIUrO)Medical and Translational Oncology, Department of Oncology, Azienda Ospedaliera Santa MariaRadiation Oncology Unit of Arezzo-Valdarno, Azienda USL Toscana Sud-Est, Ospedale Arezzo e ValdarnoMedical Oncology Unit, Ospedale Buccheri La FerlaDepartment of Diagnostics and Public Health, University of VeronaItalian Society of Uro-OncologyInstitute of Pathological Anatomy, Department of Medicine, University of UdineItalian Society of Uro-OncologyDepartment of Oncology and Hematology, Azienda Ospedaliero-Universitaria di ModenaRadiation Oncology, Dipartimento di Biomedicina e Prevenzione, Università degli Studi di Roma Tor VergataOncology Operative Unit, Santa Maria delle Grazie Hospital, ASL NA2 NORDDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of PalermoUrologia FirenzeUrology Department, USL Umbria 2School of Methodology of Clinical Research IRCCS “Sacro Cuore - Don Calabria” Hospital Negrar di ValpolicellaMedical Genetics Unit, Hospital of PerugiaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaMedical and Translational Oncology, Department of Oncology, Azienda Ospedaliera Santa MariaMedical and Translational Oncology, Department of Oncology, Azienda Ospedaliera Santa MariaAbstract Prostate cancer (PCa) ranks among the most prevalent malignancies in men, with notable associations to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) and Lynch Syndrome, both linked to germline likely pathogenetic variant/pathogenetic variant (LPV/PV) in genes involved in DNA repair. Among these genes, BRCA2 in PCa patients is the most frequently altered. Despite progresses, challenges in BRCA carriers detection persist, with a quarter of PCa cases lacking family history. To address these challenges, a multidisciplinary expert panel from six Italian Scientific Societies, formulated a care pathway to integrate BRCA testing into routine clinical practice in different Italian geographical areas. The development process, promoted by the Italian Society of Uro-Oncology (SIUrO), involved three key stages. A preliminary meeting convened teams from different Italian regions to establish minimal requirements for a mini-counseling program (defined as a pre-test consultation carried out by clinicians responsible of patients’ management) and propose care pathway models. At the same time, a comprehensive survey was launched to highlight regional variations in BRCA testing and identify eventual obstacles to testing activities. A subsequent meeting synthesized care pathway proposals and formulated a unified framework, acknowledging regional legislative variations as enriching factors. Lastly, implementation of the unified framework was promoted by the project faculty and identified regional team leaders. Survey results revealed significant regional disparities in BRCA testing, reimbursement policies, and access to genetic counseling. The proposed mini-counseling program outlined essential steps for patient identification, information provision, and multidisciplinary review, aiming to streamline BRCA testing processes. Expert recommendations emphasized offering tumor genetic testing to metastatic PCa patients eligible for PARP-i treatment and outlined criteria for genetic counseling and germline testing. Key considerations included family history and tumor characteristics. In conclusion, the proposed care pathway represents a critical step towards integrating BRCA testing into routine PCa care, aiming to optimize patient management and familial risk assessment within the constraints of the Italian healthcare system.https://doi.org/10.1186/s12885-025-13521-5BRCAProstate cancerMini-counselingGenetic counselingCare pathway |
| spellingShingle | Giulia Mammone Simona Borghesi Nicolò Borsellino Anna Caliò Roberta Ceccarelli Alessia Cimadamore Giario Natale Conti Laura Cortesi Rolando Maria D’Angelillo Gaetano Facchini Lorena Incorvaia Alberto Lapini Luigi Mearini Giovanni Pappagallo Paolo Prontera Daniela Turchetti Grazia Sirgiovanni Sergio Bracarda on behalf of the Italian Society of Uro-Oncology (SIUrO) Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies BMC Cancer BRCA Prostate cancer Mini-counseling Genetic counseling Care pathway |
| title | Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies |
| title_full | Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies |
| title_fullStr | Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies |
| title_full_unstemmed | Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies |
| title_short | Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies |
| title_sort | integrating brca testing into routine prostate cancer care a multidisciplinary approach by siuro and other italian scientific societies |
| topic | BRCA Prostate cancer Mini-counseling Genetic counseling Care pathway |
| url | https://doi.org/10.1186/s12885-025-13521-5 |
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