S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma
Abstract Background Sphingosine-1-phosphate receptor 3 (S1PR3) has been implicated in promoting tumor progression in various cancers. However, the role and molecular mechanisms of S1PR3 in oral squamous cell carcinoma (OSCC) remain poorly understood. The aims of this study were to investigate the fu...
Saved in:
| Main Authors: | Xinxia Zhou, Jinghao Liu, Xu Chen, Xinyu Zhou, Beihui Xu, Guifang Gan, Fuxiang Chen |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06582-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib
by: Jing Zhang, et al.
Published: (2025-01-01) -
Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells
by: Judy Ziener, et al.
Published: (2025-02-01) -
Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis
by: Jie Feng, et al.
Published: (2024-12-01) -
Targeting WEE1 and asciminib suppresses ABL-tyrosine kinase inhibitor-resistant chronic myeloid leukemia cells
by: Seiichi Okabe, et al.
Published: (2025-07-01) -
Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis
by: Zhuqi Huang, et al.
Published: (2025-07-01)