S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma

S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma

Abstract Background Sphingosine-1-phosphate receptor 3 (S1PR3) has been implicated in promoting tumor progression in various cancers. However, the role and molecular mechanisms of S1PR3 in oral squamous cell carcinoma (OSCC) remain poorly understood. The aims of this study were to investigate the fu...

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Bibliographic Details
Main Authors: Xinxia Zhou, Jinghao Liu, Xu Chen, Xinyu Zhou, Beihui Xu, Guifang Gan, Fuxiang Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Oral squamous cell carcinoma
Sphingosine-1-phosphate receptor 3
AKT signaling pathway
WEE1
Cell cycle
Online Access:https://doi.org/10.1186/s12967-025-06582-4
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https://doi.org/10.1186/s12967-025-06582-4

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