Retinoic acid regulates the proliferation, differentiation, and cell death of limb skeletal progenitors, contributing to establish the size and identity of the digits

Retinoic acid regulates the proliferation, differentiation, and cell death of limb skeletal progenitors, contributing to establish the size and identity of the digits

Abstract Background The development of the digits (fingers/toes) provides an excellent model for analyzing the molecular regulation of skeletal morphogenesis in vertebrates. Digits develop in the autopod as radial chondrogenic condensations separated by interdigital spaces containing undifferentiate...

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Bibliographic Details
Main Authors: Cristina Duarte-Olivenza, Goretti Moran, Juan M. Hurle, Juan A. Montero, Carlos I. Lorda-Diez
Format: Article
Language:English
Published: BMC 2025-07-01
Series:EvoDevo
Subjects:
Morphogenetic cell death
Citral
Retinoic acid gradient
Raldh2
Cyp26a1
Digit identity
Online Access:https://doi.org/10.1186/s13227-025-00248-4
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https://doi.org/10.1186/s13227-025-00248-4

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