Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels

Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels

Abstract We previously reported that high mobility group box 1 (HMGB1), a danger-associated molecular pattern (DAMP), increases intracellular iron levels in the postischemic brain by upregulating hepcidin, a key regulator of iron homeostasis, triggering ferroptosis. Since hepatocytes are the primary...

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Main Authors: Dashdulam Davaanyam, Song-I Seol, Sang-A Oh, Hahnbi Lee, Ja-Kyeong Lee
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01314-y
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https://doi.org/10.1038/s12276-024-01314-y

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