PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice

PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice

Abstract The genetic causes of oocyte meiotic deficiency (OMD), a form of primary infertility characterised by the production of immature oocytes, remain largely unexplored. Using whole exome sequencing, we found that 26% of a cohort of 23 subjects with OMD harboured the same homozygous nonsense pat...

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Main Authors: Marie Christou‐Kent, Zine‐Eddine Kherraf, Amir Amiri‐Yekta, Emilie Le Blévec, Thomas Karaouzène, Béatrice Conne, Jessica Escoffier, Said Assou, Audrey Guttin, Emeline Lambert, Guillaume Martinez, Magalie Boguenet, Selima Fourati Ben Mustapha, Isabelle Cedrin Durnerin, Lazhar Halouani, Ouafi Marrakchi, Mounir Makni, Habib Latrous, Mahmoud Kharouf, Charles Coutton, Nicolas Thierry‐Mieg, Serge Nef, Serge P Bottari, Raoudha Zouari, Jean Paul Issartel, Pierre F Ray, Christophe Arnoult
Format: Article
Language:English
Published: Springer Nature 2018-04-01
Series:EMBO Molecular Medicine
Subjects:
female sterility
oocyte developmental competence
oocyte maturation arrest
oocyte maturation failure
Patl2
Online Access:https://doi.org/10.15252/emmm.201708515
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https://doi.org/10.15252/emmm.201708515

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