The Role of PDGFs and PDGFRs in Colorectal Cancer
Introduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide. Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis. Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and decipheri...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/4708076 |
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| author | Roberta M. Manzat Saplacan Loredana Balacescu Claudia Gherman Romeo I. Chira Anca Craiu Petru A. Mircea Cosmin Lisencu Ovidiu Balacescu |
| author_facet | Roberta M. Manzat Saplacan Loredana Balacescu Claudia Gherman Romeo I. Chira Anca Craiu Petru A. Mircea Cosmin Lisencu Ovidiu Balacescu |
| author_sort | Roberta M. Manzat Saplacan |
| collection | DOAJ |
| description | Introduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide. Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis. Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge. The aim of our study is to point out the diagnosis and prediction role of PDGF family and their receptors in colorectal carcinogenesis. Material and Methods. A systematic search in Medline and PubMed for studies reporting the role of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in tumor biology related to CRC was made. Results. PDGFs are important growth factors for normal tissue growth and division, with an important role in blood vessel formation. PDGFs/PDGFRs signaling pathway has been demonstrated to be involved in angiogenesis mainly by targeting pericytes and vascular smooth muscle cells. High levels of PDGF-BB were reported in CRC patients compared to those with adenomas, while elevated levels of PDGFR α/β in the stroma of CRC patients were correlated with invasion and metastasis. Moreover, PDGF-AB and PDGF-C were correlated with early diagnosis, cancer grading, and metastatic disease. Conclusions. Both PDGFs and PDGFRs families play an important role in colorectal carcinogenesis and could be considered to be investigated as useful biomarkers both for diagnosis and treatment of CRC. |
| format | Article |
| id | doaj-art-2a0e95a0a706408795d3bb46d92207c3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2a0e95a0a706408795d3bb46d92207c32025-02-03T05:57:07ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/47080764708076The Role of PDGFs and PDGFRs in Colorectal CancerRoberta M. Manzat Saplacan0Loredana Balacescu1Claudia Gherman2Romeo I. Chira3Anca Craiu4Petru A. Mircea5Cosmin Lisencu6Ovidiu Balacescu7First Medical Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 3-5 Clinicilor Street, 400006 Cluj-Napoca, RomaniaDepartment of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaDepartment of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaFirst Medical Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 3-5 Clinicilor Street, 400006 Cluj-Napoca, RomaniaThe Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor” Cluj-Napoca, 5 Constanta Street, 400158 Cluj-Napoca, RomaniaFirst Medical Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 3-5 Clinicilor Street, 400006 Cluj-Napoca, RomaniaDepartment of Surgical and Gynecological Oncology, University of Medicine and Pharmacy “Iuliu Hatieganu”, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaDepartment of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaIntroduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide. Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis. Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge. The aim of our study is to point out the diagnosis and prediction role of PDGF family and their receptors in colorectal carcinogenesis. Material and Methods. A systematic search in Medline and PubMed for studies reporting the role of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in tumor biology related to CRC was made. Results. PDGFs are important growth factors for normal tissue growth and division, with an important role in blood vessel formation. PDGFs/PDGFRs signaling pathway has been demonstrated to be involved in angiogenesis mainly by targeting pericytes and vascular smooth muscle cells. High levels of PDGF-BB were reported in CRC patients compared to those with adenomas, while elevated levels of PDGFR α/β in the stroma of CRC patients were correlated with invasion and metastasis. Moreover, PDGF-AB and PDGF-C were correlated with early diagnosis, cancer grading, and metastatic disease. Conclusions. Both PDGFs and PDGFRs families play an important role in colorectal carcinogenesis and could be considered to be investigated as useful biomarkers both for diagnosis and treatment of CRC.http://dx.doi.org/10.1155/2017/4708076 |
| spellingShingle | Roberta M. Manzat Saplacan Loredana Balacescu Claudia Gherman Romeo I. Chira Anca Craiu Petru A. Mircea Cosmin Lisencu Ovidiu Balacescu The Role of PDGFs and PDGFRs in Colorectal Cancer Mediators of Inflammation |
| title | The Role of PDGFs and PDGFRs in Colorectal Cancer |
| title_full | The Role of PDGFs and PDGFRs in Colorectal Cancer |
| title_fullStr | The Role of PDGFs and PDGFRs in Colorectal Cancer |
| title_full_unstemmed | The Role of PDGFs and PDGFRs in Colorectal Cancer |
| title_short | The Role of PDGFs and PDGFRs in Colorectal Cancer |
| title_sort | role of pdgfs and pdgfrs in colorectal cancer |
| url | http://dx.doi.org/10.1155/2017/4708076 |
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