Labeling and Biological Evaluation of 99m Tc-HYNIC-Trastuzumab as a Potential Radiopharmaceutical for In Vivo Evaluation of HER2 Expression in Breast Cancer

Labeling and Biological Evaluation of 99m Tc-HYNIC-Trastuzumab as a Potential Radiopharmaceutical for In Vivo Evaluation of HER2 Expression in Breast Cancer

The amplification of HER2 gene has been described in several tumor types, mainly breast cancer with a subsequent increase in HER2 protein expression. Trastuzumab is a humanized monoclonal antibody that recognizes selectively the HER2 extracellular domain. The objective of the present work was to sta...

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Bibliographic Details
Main Authors: Victoria Calzada, Fernanda Garcia, Marcelo Fernández, Williams Porcal, Thomas Quinn, Omar Alonso, Juan Pablo Gambini, Pablo Cabral
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2013-01-01
Series:World Journal of Nuclear Medicine
Subjects:
Breast cancer
hydrazinonicotinamide
scintigraphy
99m Tc-labeling
trastuzumab
Online Access:http://www.wjnm.org/article.asp?issn=1450-1147;year=2013;volume=12;issue=1;spage=27;epage=32;aulast=Calzada
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http://www.wjnm.org/article.asp?issn=1450-1147;year=2013;volume=12;issue=1;spage=27;epage=32;aulast=Calzada

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