Flavonoids from Polygonum hydropiper L. regulate PCV2-induced oxidative stress of RAW264.7 cells via Pi3k/AKT and Nrf2/HO-1 signaling pathways

Flavonoids from Polygonum hydropiper L. regulate PCV2-induced oxidative stress of RAW264.7 cells via Pi3k/AKT and Nrf2/HO-1 signaling pathways

Abstract Flavonoid n-butanol (FNB) possess diverse pharmacological properties. This study aimed to explore the mechanism of FNB in regulating oxidative response in PCV2-infected RAW264.7 cells. PCV2-infected macrophages were treated with FNB, and oxidative stress markers, antioxidant enzyme activiti...

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Bibliographic Details
Main Authors: Qi Chen, Qiuhua Wang, Yi Zhao, Xiaodong Xie, HeYu Feng, Yingyi Wei, Meiling Yu, Xianhui Pan, Tingjun Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
FNB
PCV2
Oxidative stress
Molecular mechanism
Online Access:https://doi.org/10.1038/s41598-025-14362-9
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https://doi.org/10.1038/s41598-025-14362-9

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