Studies on the mechanism of ototoxic action of cisplatin and the antagonistic effect of polyphenolic compounds

Cisplatin is a highly effective broad-spectrum anticancer drug, but its severe ototoxicity limits its clinical application. Cisplatin ototoxicity is mainly manifested as irreversible hearing loss, and its mechanism involves various pathways such as DNA damage, oxidative stress, inflammatory response...

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Bibliographic Details
Main Authors: Shengyu Han, Jinjun Sun, Wenpeng Li, Jihong Li, Haoming Yu, Shuai Wang, Yuhua Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586243/full
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