Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

Abstract The interaction of tumor cells and their microenvironment is thought to be a key factor in tumor development. We present spatial RNA profiles obtained from 30 lung adenocarcinoma patients at the non-invasive and later invasive stages. We use spatial transcriptome sequencing data in conjunct...

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Main Authors: Yuma Takano, Jun Suzuki, Kotaro Nomura, Gento Fujii, Junko Zenkoh, Hitomi Kawai, Yuta Kuze, Yukie Kashima, Satoi Nagasawa, Yuka Nakamura, Motohiro Kojima, Katsuya Tsuchihara, Masahide Seki, Akinori Kanai, Daisuke Matsubara, Takashi Kohno, Masayuki Noguchi, Akihiro Nakaya, Masahiro Tsuboi, Genichiro Ishii, Yutaka Suzuki, Ayako Suzuki
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54671-7
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https://doi.org/10.1038/s41467-024-54671-7

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