PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway

PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway

Abstract Multiple myeloma (MM) is a cancer of plasma cells caused by abnormal gene expression and interactions within the bone marrow (BM) niche. The BM environment significantly influences the progression of MM. Celastrol, a natural compound derived from traditional Chinese medicine, exhibits signi...

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Main Authors: Zhendong Deng, Shanliang Sun, Nian Zhou, Yumeng Peng, Long Cheng, Xichao Yu, Yuxia Yuan, Mengjie Guo, Min Xu, Yuexin Cheng, Fan Zhou, Nianguang Li, Ye Yang, Chunyan Gu
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
dishevelled 3
eltrombopag
multiple myeloma
pyridoxine‐5′‐phosphate oxidase
wnt/β‐catenin pathway
Online Access:https://doi.org/10.1002/advs.202407681
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https://doi.org/10.1002/advs.202407681

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