Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

<h4>Background</h4>Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in sever...

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Main Authors: Stephen R Doyle, Catherine Bourguinat, Hugues C Nana-Djeunga, Jonas A Kengne-Ouafo, Sébastien D S Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A Boakye, Mike Y Osei-Atweneboana, Michel Boussinesq, Roger K Prichard, Warwick N Grant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005816&type=printable
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https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005816&type=printable

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