Mangiferin mitigates neurological deficits and ferroptosis via NRF2/ARE pathway activation in cerebral ischemia-reperfusion rats

Mangiferin mitigates neurological deficits and ferroptosis via NRF2/ARE pathway activation in cerebral ischemia-reperfusion rats

IntroductionFerroptosis is a newly described form of nonapoptotic, iron-dependent cell death that plays an essential role in the pathogenesis of ischemic stroke. Targeting ferroptosis may be an effective way to treat ischemic stroke. Mangiferin (MGF) is a natural polyphenol that has been shown to pr...

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Bibliographic Details
Main Authors: Chenjia Peng, Yang Zhang, Jiaqing Chai, Hengbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
MGF
ischemic stroke
ferroptosis
Nrf2/ARE pathway
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1577954/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1577954/full

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