Increasing donor kidney age significantly aggravates the negative effect of pretransplant donor-specific anti-HLA antibodies on kidney graft survival

Increasing donor kidney age significantly aggravates the negative effect of pretransplant donor-specific anti-HLA antibodies on kidney graft survival

Background and hypothesisThe presence of donor-specific anti-HLA antibodies before kidney transplantation (preDSAs) is associated with decreased graft survival. The hypothesis that increasing donor kidney age is negatively associated with the impact of preDSA on graft survival was investigated.Metho...

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Bibliographic Details
Main Authors: Michiel G. H. Betjes, Judith A. Kal-van Gestel, Dave Roelen, Marcia M. L. Kho, Sebastian Heidt, Annelies E. de Weerd, Jacqueline van de Wetering
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
age donor kidney
antibody-mediated rejection
donor-specific anti-HLA antibodies
graft survival
kidney transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574324/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574324/full

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