A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia

A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia

Ischemic stroke is a significant threat to human health. Currently, there is a lack of effective treatments for stroke, and progress in new neuron-centered drug target development is relatively slow. On the other hand, studies have demonstrated that brain microvascular endothelial cells (BMECs) are...

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Bibliographic Details
Main Authors: Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Redox Biology
Subjects:
Systems biology
Brain microvascular endothelial cell
Ischemic stroke
Oxidative stress
Model-informed drug target assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724003938
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