BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization

BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization

Abstract Aims This study compares the suppression of Mitogen‐activated protein kinase (MAPK) signalling and early resistance potential between a proteolysis‐targeting chimera (PROTAC) and inhibitors targeting BRAFV600E. Methods We performed a detailed in silico analysis of the transcriptomic landsca...

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Bibliographic Details
Main Authors: Solomon O. Alhassan, Zakaria Y. Abd Elmageed, Youssef Errami, Guangdi Wang, Joe A. Abi‐Rached, Emad Kandil, Mourad Zerfaoui
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
BRAFV600E
differentiation state
MAPK pathway
melanoma
MITF
PROTAC
Online Access:https://doi.org/10.1002/ctm2.70251
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https://doi.org/10.1002/ctm2.70251

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