N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity

N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity

Ischemic stroke is a life-threatening disease, its pathological progression involves multiple factors, including oxidative stress, apoptosis, and ferroptosis. Our previous study demonstrated that hybridizing N-butylphthalide (NBP) with ligustrazine (TMP) yielded promising anti-ischemic compounds. In...

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Bibliographic Details
Main Authors: Guangyu Li, Haiyan Xiao, Chenwei Zuo, Haochen Xie, Xiaolin Wang, Jiaxin Wang, Ying Liu, Quanxing Hou, Guibo Sun, Yu Tian
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Redox Biology
Subjects:
NBP
TMP
Ischemic stroke
KEAP1-NRF2
Oxidative stress
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003489
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