Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation

Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation

Fusobacterium nucleatum (F. nucleatum) has emerged as a potential contributor to ulcerative colitis (UC) pathogenesis, although the specific mechanisms remain incompletely understood. This study demonstrates that F. nucleatum promotes colitis by disrupting intestinal barrier integrity, inducing apop...

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Bibliographic Details
Main Authors: Zixuan Xiang, Xiangyun Li, Xiaoli Wang, Beiying Deng, Haodong He, Miao Xu, Xiaohan Wu, Cheng Tan, Yafei Liu, Baoping Yu, Jixiang Zhang, Weiguo Dong
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Fusobacterium nucleatum
ulcerative colitis
STAT3
Acetyl-CoA
acetylation
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2489070
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2489070

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