Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway

Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway

Abstract Background Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. Despite the availability of various targeted drugs for RA, these treatments are limited by adverse reactions, warranting new treatment approaches. Suberosi...

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Bibliographic Details
Main Authors: Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Synovitis
Fibroblast-like synoviocyte
Macrophage polarization
Suberosin
JAK-STAT
Online Access:https://doi.org/10.1186/s13075-025-03481-3
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https://doi.org/10.1186/s13075-025-03481-3

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