Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival

Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival

Abstract Background EpCAM (epithelial cell adhesion molecule) is a key regulator of epithelial cell–cell adhesion, signal transduction, tissue regeneration, and serves as a stem cell marker. It is frequently overexpressed in epithelial cancers and is linked to tumor progression, survival, and metast...

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Main Authors: Priyanka S. Dhotare, Audrey C. Bochi-Layec, Timothy P. Fleming, William E. Gillanders, Ross M. Bremner, Kailas D. Sonawane, Narendra V. Sankpal
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
EpCAM
Mutation
Cancer
Molecular modelling
Online Access:https://doi.org/10.1186/s12885-025-14455-8
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https://doi.org/10.1186/s12885-025-14455-8

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