RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma

RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma

Hu Antigen R, also known as ELAVL1 (HuR), is a key posttranscriptional regulator in eukaryotic cells. HuR overexpression promotes several malignancies, including head and neck squamous cell carcinoma (HNSCC). However, its immune dysfunction-associated tumorigenesis pathways remain unknown. We examin...

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Bibliographic Details
Main Authors: Mrinmoyee Majumder, Harinarayanan Janakiraman, Paramita Chakraborty, Anitha Vijayakumar, Sari Mayhue, Hong Yu, Toros Dincman, Romeo Martin, Elizabeth O'Quinn, Shikhar Mehrotra, Viswanathan Palanisamy
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Oral Oncology Reports
Subjects:
Oral squamous cell carcinoma
RNA-Binding proteins
T-regulatory cells
Pyrvinium pamoate
Immune infiltration
Antitumor effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024001420
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