Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities

Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities

Super-enhancers (SEs) are dynamic chromatin structures that function as epigenetic hubs, orchestrating cell-type-specific transcriptional programs crucial for immune cell differentiation, functional specialization, and adaptive responses. These enhancer clusters integrate transcription factor (TF) n...

Full description

Saved in:
Bibliographic Details
Main Authors: Xin Lai, Caizhi Li, Xinglinzi Tang, Xinyi Luo, Feiyan Wu, Yuhong Liang, Bihui Huang, Hang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
super enhancer
immune system
transcription regulation
cell signaling
pathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1652398/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1652398/full

Similar Items