Supra-Physiological Levels of Magnesium Counteract the Inhibitory Effect of Zoledronate on RANKL-Dependent Osteoclastogenesis

Supra-Physiological Levels of Magnesium Counteract the Inhibitory Effect of Zoledronate on RANKL-Dependent Osteoclastogenesis

Bisphosphonates (BPs) are drugs used to cure metabolic diseases like osteoporosis and oncological conditions, such as multiple myeloma and bone metastases. The pharmacological activity of these compounds is mediated by their capacity to induce a systemic osteoclast depletion, finally resulting in re...

Full description

Saved in:
Bibliographic Details
Main Authors: Lorenzo Caselli, Lisa De Pasquale, Rossella Palumbo, Silvia Ricchiuto, Monica Montanari, Sebastiano Rontauroli, Alessandra Ottani, Ruggiero Norfo, Tommaso Zanocco-Marani, Alexis Grande
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biology
Subjects:
osteoclasts
magnesium
bisphosphonates
zoledronate
denosumab
ONJ
Online Access:https://www.mdpi.com/2079-7737/14/5/533
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2079-7737/14/5/533

Similar Items