α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid
IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum α-klo...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1599402/full |
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| Summary: | IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum α-klotho was also analyzed in females and males of different ages and whether it was associated with Aβ42, Aβ40, or the Aβ42/40 ratio. Furthermore, CSF and serum α-klotho were analyzed in women and men with dementia and controls and whether they were associated with CSF Aβ levels.ResultsHT was associated with increased CSF α-klotho levels. Furthermore, α-klotho and Aβ levels were correlated in a species- and cognitive health-dependent fashion. Higher CSF and serum levels of α-klotho were seen in controls than in patients with dementia.DiscussionUnderstanding the species differences in the beneficial effects of α-klotho on CSF Aβ physiology should open new avenues for treating AD. |
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| ISSN: | 1663-4365 |