α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum α-klo...

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Bibliographic Details
Main Authors: Jacob Raber, Alexandra Pederson, Emily Bunnell, Nora Mattek, Nora E. Gray, Steven G. Kohama, Alison R. Weiss, Joseph F. Quinn, Henryk F. Urbanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
α-klotho
apoE
Aβ
CSF
serum
rhesus macaques
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1599402/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1599402/full

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