A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses

A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses

Background: HIV-1 envelope (Env) variable loops 1 and 2 (V1V2) directed non-neutralizing antibodies were a correlate of decreased transmission risk in the RV144 vaccine trial. Thus, the elicitation and breadth of antibody responses against the V1V2 of HIV-1 Env are important considerations for HIV-1...

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Main Authors: Xiaoying Shen, Bette Korber, Rachel L. Spreng, Sheetal S. Sawant, Allan deCamp, Arthur S. McMillan, Ryan Mathura, Susan Zolla-Pazner, Abraham Pinter, Robert Parks, Cindy Bowman, Laura Sutherland, Richard Scearce, Nicole L. Yates, David C. Montefiori, Barton F. Haynes, Georgia D. Tomaras
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
HIV vaccine
antibody response
polyvalent vaccine
breadth
V1V2 response
Online Access:https://www.mdpi.com/2076-393X/13/2/133
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