Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias

Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias

ABSTRACT Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or atrial flutter (AFIB/AFL). Despite its efficacy, sotalol's use is limited by its potential to cause life‐threatening ventricular arrhythmias due to QT interval prolongati...

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Main Authors: Venkata K. Yellepeddi, Mohamed Ismail, T. Jared Bunch, Thomas F. Deering, Richard Holubkov, Robert Kennedy, Suneet Mittal, Marco Perez, Jonathan P. Piccini, Parash Pokharel, Salvatore Savona, Nishant Verma, Benjamin Steinberg, Kevin Watt
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
atrial fibrillation
intravenous Sotalol
pharmacodynamics
PK/PD modeling
population pharmacokinetics
QT prolongation
Online Access:https://doi.org/10.1002/psp4.13302
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https://doi.org/10.1002/psp4.13302

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