Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy

Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy

ABSTRACT: High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress. Studies have shown that autophagy is impaired in the mammary glands of ketotic cows, and enhancing autophagy mitigates oxidative...

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Main Authors: Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J. Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Journal of Dairy Science
Subjects:
autophagy
clinical ketosis
CUL3
oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030225000797
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