NGS coverage accurately predicts MET and HER2 (ERBB2) gene amplifications in a real-world non-small cell lung cancer cohort

NGS coverage accurately predicts MET and HER2 (ERBB2) gene amplifications in a real-world non-small cell lung cancer cohort

BackgroundFluorescence in situ hybridization (FISH) is the current standard for detecting gene amplifications, yet its low throughput and practical constraints call for alternative methods. This study evaluates next-generation sequencing (NGS) as a potential tool for accurately predicting gene ampli...

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Bibliographic Details
Main Authors: Adam Kowalewski, Janna Siemanowski-Hrach, Thomas Stehle, Jan Rehker, Udo Siebolts, Sabine Merkelbach-Bruse, Carina Heydt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
NGS
coverage
amplification
met
HER2
lung
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1618509/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1618509/full

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