Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells

Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells

Infection of influenza A virus (IAV) can trigger exaggerated pulmonary inflammation and induce acute lung injury (ALI). Limiting IAV replication and alleviation of pulmonary inflammation are two important therapeutic strategies for influenza virus infection. Recent studies have shown that hypoxia in...

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Bibliographic Details
Main Authors: Caiqi Zhao, Jie Chen, Lianping Cheng, Kaifeng Xu, Yiyu Yang, Xiao Su
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Influenza A virus
autophagy
HIF-1α
glycolysis
AMPKα
ULK1
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1742585
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https://www.tandfonline.com/doi/10.1080/22221751.2020.1742585

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