Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.

Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.

The immune system must discriminate between pathogenic and nonpathogenic microbes in order to initiate an appropriate response. Toll-like receptors (TLRs) detect microbial components common to both pathogenic and nonpathogenic bacteria, whereas Nod-like receptors (NLRs) sense microbial components in...

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Main Authors: Sunny Shin, Christopher L Case, Kristina A Archer, Catarina V Nogueira, Koichi S Kobayashi, Richard A Flavell, Craig R Roy, Dario S Zamboni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000220&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000220&type=printable

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